RCT tackles the "treat the urine, not the patient" reflex in delirious elders
The vanguard results of Fralick et al.'s multicentre randomized trial — antibiotics vs. no antibiotics for older adults with delirium who have pyuria or bacteriuria but no other signs of a UTI — are out in the Journal of the American Geriatrics Society. It's the first pragmatic RCT to directly test a scenario you see most nights: an elderly admit who's confused, the UA comes back "dirty," and the question is whether antibiotics actually help the delirium or just expose the patient to C. diff and resistance.
This is a recent publication rather than a 48-hour headline, but it's worth flagging because it's squarely in your wheelhouse and the dedup log hasn't seen it. The systematic-review base behind it was thin; this is the start of real trial-grade evidence on a daily decision.